Aggressive lipid-lowering therapy before and after revascularization in patients with stable coronary artery disease

Abstract

The review presents data on the effectiveness of lipid profile correction with maximum doses of statins, primarily atorvastatin, and lipoprotein apheresis. The results of large-scale studies and meta-analyses evaluating the use of statins before and after coronary artery bypass surgery and stenting to reduce the risk of both early and late cardiovascular complications, and the need for revascularization of the myocardium, were analyzed. Lipid apheresis in patients with coronary artery disease who underwent coronary stenting or bypass surgery, and with hypercholesterolemia refractory to lipotropic therapy, is associated with reduced risk of in-stent restenosis, as well as destruction of bypass. Therefore, this method can be recommended to be used in patients with refractory hyperlipidemia undergoing myocardial revascularization.

Keywords

• statins
• atorvastatin
• apheresis
• coronary stenting
• heart bypass
• статины
• аторвастатин
• аферез
• коронарное стентирование
• коронарное шунтирование