Nature Communications (Sep 2018)
Contribution of allelic imbalance to colorectal cancer
- Kimmo Palin,
- Esa Pitkänen,
- Mikko Turunen,
- Biswajyoti Sahu,
- Päivi Pihlajamaa,
- Teemu Kivioja,
- Eevi Kaasinen,
- Niko Välimäki,
- Ulrika A. Hänninen,
- Tatiana Cajuso,
- Mervi Aavikko,
- Sari Tuupanen,
- Outi Kilpivaara,
- Linda van den Berg,
- Johanna Kondelin,
- Tomas Tanskanen,
- Riku Katainen,
- Marta Grau,
- Heli Rauanheimo,
- Roosa-Maria Plaketti,
- Aurora Taira,
- Päivi Sulo,
- Tuomo Hartonen,
- Kashyap Dave,
- Bernhard Schmierer,
- Sandeep Botla,
- Maria Sokolova,
- Anna Vähärautio,
- Kornelia Gladysz,
- Halit Ongen,
- Emmanouil Dermitzakis,
- Jesper Bertram Bramsen,
- Torben Falck Ørntoft,
- Claus Lindbjerg Andersen,
- Ari Ristimäki,
- Anna Lepistö,
- Laura Renkonen-Sinisalo,
- Jukka-Pekka Mecklin,
- Jussi Taipale,
- Lauri A. Aaltonen
Affiliations
- Kimmo Palin
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Esa Pitkänen
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Mikko Turunen
- Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki
- Biswajyoti Sahu
- Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki
- Päivi Pihlajamaa
- Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki
- Teemu Kivioja
- Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki
- Eevi Kaasinen
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Niko Välimäki
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Ulrika A. Hänninen
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Tatiana Cajuso
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Mervi Aavikko
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Sari Tuupanen
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Outi Kilpivaara
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Linda van den Berg
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Johanna Kondelin
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Tomas Tanskanen
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Riku Katainen
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Marta Grau
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Heli Rauanheimo
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Roosa-Maria Plaketti
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Aurora Taira
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Päivi Sulo
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Tuomo Hartonen
- Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki
- Kashyap Dave
- Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Bernhard Schmierer
- Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Sandeep Botla
- Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Maria Sokolova
- Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki
- Anna Vähärautio
- Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki
- Kornelia Gladysz
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- Halit Ongen
- Genetic Medicine and Development, University of Geneva Medical School-CMU
- Emmanouil Dermitzakis
- Genetic Medicine and Development, University of Geneva Medical School-CMU
- Jesper Bertram Bramsen
- Department of Molecular Medicine, Aarhus University Hospital
- Torben Falck Ørntoft
- Department of Molecular Medicine, Aarhus University Hospital
- Claus Lindbjerg Andersen
- Department of Molecular Medicine, Aarhus University Hospital
- Ari Ristimäki
- Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki
- Anna Lepistö
- Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki
- Laura Renkonen-Sinisalo
- Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki
- Jukka-Pekka Mecklin
- Department of Surgery, Jyväskylä Central Hospital
- Jussi Taipale
- Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki
- Lauri A. Aaltonen
- Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki
- DOI
- https://doi.org/10.1038/s41467-018-06132-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network of transcription factors that may contribute to colorectal tumorigenesis.
