Multi-Faceted Post-Transcriptional Functions of HIV-1 Rev

Abstract

Post-transcriptional regulation of HIV-1 gene expression is largely governed by the activities of the viral Rev protein. In this minireview, the multiple post-transcriptional activities of Rev in the export of partially spliced and unspliced HIV-1 RNAs from the nucleus to the cytoplasm, in the translation of HIV-1 transcripts, and in the packaging of viral genomic RNAs are reviewed in brief.

Keywords

• Rev
• CRM1
• DDX3
• RNA export
• RNA translation
• RNA packaging