Nature Communications (Nov 2022)
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
- Nikaïa Smith,
- Céline Possémé,
- Vincent Bondet,
- Jamie Sugrue,
- Liam Townsend,
- Bruno Charbit,
- Vincent Rouilly,
- Violaine Saint-André,
- Tom Dott,
- Andre Rodriguez Pozo,
- Nader Yatim,
- Olivier Schwartz,
- Minerva Cervantes-Gonzalez,
- Jade Ghosn,
- Paul Bastard,
- Jean Laurent Casanova,
- Tali-Anne Szwebel,
- Benjamin Terrier,
- Niall Conlon,
- Cliona O’Farrelly,
- Clíona Ní Cheallaigh,
- Nollaig M. Bourke,
- Darragh Duffy
Affiliations
- Nikaïa Smith
- Translational Immunology Unit, Institut Pasteur, Université Paris Cité
- Céline Possémé
- Translational Immunology Unit, Institut Pasteur, Université Paris Cité
- Vincent Bondet
- Translational Immunology Unit, Institut Pasteur, Université Paris Cité
- Jamie Sugrue
- School of Biochemistry and Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Liam Townsend
- Discipline of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin
- Bruno Charbit
- Institut Pasteur, Université Paris Cité, CBUTechS, Center for Translational Research
- Vincent Rouilly
- Datactix
- Violaine Saint-André
- Translational Immunology Unit, Institut Pasteur, Université Paris Cité
- Tom Dott
- Institut Pasteur, Université Paris Cité, CBUTechS, Center for Translational Research
- Andre Rodriguez Pozo
- Translational Immunology Unit, Institut Pasteur, Université Paris Cité
- Nader Yatim
- Translational Immunology Unit, Institut Pasteur, Université Paris Cité
- Olivier Schwartz
- Department of Virology, Virus and Immunity Unit, Institut Pasteur
- Minerva Cervantes-Gonzalez
- Infectious and Tropical Diseases Department, AP-HP, Hôpital Bichat
- Jade Ghosn
- Infectious and Tropical Diseases Department, AP-HP, Hôpital Bichat
- Paul Bastard
- Department of Pediatrics, Necker Hospital for Sick Children, AP-HP
- Jean Laurent Casanova
- Department of Pediatrics, Necker Hospital for Sick Children, AP-HP
- Tali-Anne Szwebel
- Institut Cochin, APHP
- Benjamin Terrier
- Institut Cochin, APHP
- Niall Conlon
- Department of Immunology, St James’s Hospital
- Cliona O’Farrelly
- School of Biochemistry and Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Clíona Ní Cheallaigh
- Discipline of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin
- Nollaig M. Bourke
- Discipline of Medical Gerontology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin
- Darragh Duffy
- Translational Immunology Unit, Institut Pasteur, Université Paris Cité
- DOI
- https://doi.org/10.1038/s41467-022-34895-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
The interferon response has been shown to be linked to severity of SARS-CoV-2 infection and is an essential component of the immune response to COVID-19. Here the authors stratify patients according to COVID-19 severity and asses the interferon response showing defective responses in severe infection and highlight the importance of assay variables and confounding factors that impact the detection of interferon.
