Dynamics of blood lipid profile indicators in a perspective sample of young people aging 19–22 years in Novosibirsk for the fifth year period (2014–2019)

Abstract

Lipid levels in children correlate with adult lipid levels, and dyslipidemia is a major risk factor for developing of cardiovascular diseases. We aimed to study the dynamic levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL cholesterol), high-density lipoprotein cholesterol (HDL cholesterol) and triglycerides (TG) in young people from 2014 to 2019. Material and methods. In 2014 a cohort of 105 people was formed based on the cross-sectional population survey of schoolchildren, in which the lipid profile was analyzed. In 2019, a second analysis was conducted. Blood TC, HDL cholesterol, TG were measured by enzymatic methods. LDL cholesterol was calculated with Friedwald’s formula. Results. From 2014 to 2019 TC levels increased from 154.5 to 163.0 mg/dl (p = 0.005), due to the subgroup of men. HDL cholesterol also increased from 44.5 to 62.5 mg/dl (p < 0.001) in both men and women. A general downward trend in LDL cholesterol is noticeable from 2014 to 2019. However, a significant difference was obtained only in the female subgroup (96.8 and 86.3 mg/dl, p = 0.038). TG levels increased from 2014 to 2019 (from 61.0 to 64.0 mg/dl), due to the subgroup of men. TC levels were higher in the female subgroup in 2014 (p = 0.014), HDL cholesterol levels were higher in the female subgroup in 2014 (p = 0.022) and 2019 (p <0.001), TG levels were higher in the male subgroup in 2019 (p = 0.021). Levels of LDL cholesterol were not significantly different between men and women in both years. Conclusions. Our results demonstrate the regular dynamics of the lipid profile over a five-year period, with an increase in the levels of TG and TC and a decrease in the level of LDL cholesterol, in young people.

Keywords

• dyslipidemia
• lipid profile
• adolescents
• youth
• dynamics of the lipid profile