Nature Communications (Sep 2017)
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
- Jong Hyun Kim,
- Chulho Lee,
- Minji Lee,
- Haipeng Wang,
- Kibum Kim,
- Seung Joon Park,
- Ina Yoon,
- Jayun Jang,
- Hanchao Zhao,
- Hoi Kyoung Kim,
- Nam Hoon Kwon,
- Seung Jae Jeong,
- Hee Chan Yoo,
- Jae Hyun Kim,
- Jee Sun Yang,
- Myeong Youl Lee,
- Chang Woo Lee,
- Jieun Yun,
- Soo Jin Oh,
- Jong Soon Kang,
- Susan A. Martinis,
- Kwang Yeon Hwang,
- Min Guo,
- Gyoonhee Han,
- Jung Min Han,
- Sunghoon Kim
Affiliations
- Jong Hyun Kim
- Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University
- Chulho Lee
- Department of Integrated OMICS for Biomedical Science, Yonsei University
- Minji Lee
- Department of Integrated OMICS for Biomedical Science, Yonsei University
- Haipeng Wang
- Department of Cancer Biology, The Scripps Research Institute, Scripps Florida
- Kibum Kim
- Department of Integrated OMICS for Biomedical Science, Yonsei University
- Seung Joon Park
- Department of Integrated OMICS for Biomedical Science, Yonsei University
- Ina Yoon
- Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University
- Jayun Jang
- Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University
- Hanchao Zhao
- Department of Biochemistry, University of Illinois at Urbana
- Hoi Kyoung Kim
- Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University
- Nam Hoon Kwon
- Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University
- Seung Jae Jeong
- Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University
- Hee Chan Yoo
- College of Pharmacy, Yonsei University
- Jae Hyun Kim
- Department of Integrated OMICS for Biomedical Science, Yonsei University
- Jee Sun Yang
- Translational Research Center for Protein Function Control, Department of Biotechnology, Yonsei University
- Myeong Youl Lee
- Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology
- Chang Woo Lee
- Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology
- Jieun Yun
- Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology
- Soo Jin Oh
- Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology
- Jong Soon Kang
- Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology
- Susan A. Martinis
- Department of Biochemistry, University of Illinois at Urbana
- Kwang Yeon Hwang
- Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University
- Min Guo
- Department of Cancer Biology, The Scripps Research Institute, Scripps Florida
- Gyoonhee Han
- Department of Integrated OMICS for Biomedical Science, Yonsei University
- Jung Min Han
- Department of Integrated OMICS for Biomedical Science, Yonsei University
- Sunghoon Kim
- Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University
- DOI
- https://doi.org/10.1038/s41467-017-00785-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. Here, the authors identify inhibitors of the GTPase activating function of LRS, not affecting its catalytic activity, and demonstrate that the leucine sensor function of LRS can be a new target for mTORC1 inhibition.
