Nature Communications (Jul 2019)
Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions
- James R. Birtley,
- Mohammad Alomary,
- Elisa Zanini,
- Jane Antony,
- Zachary Maben,
- Grant C. Weaver,
- Claudia Von Arx,
- Manuela Mura,
- Aline T. Marinho,
- Haonan Lu,
- Eloise V. N. Morecroft,
- Evdoxia Karali,
- Naomi E. Chayen,
- Edward W. Tate,
- Mollie Jurewicz,
- Lawrence J. Stern,
- Chiara Recchi,
- Hani Gabra
Affiliations
- James R. Birtley
- Department of Pathology, University of Massachusetts Medical School
- Mohammad Alomary
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Elisa Zanini
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Jane Antony
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Zachary Maben
- Department of Pathology, University of Massachusetts Medical School
- Grant C. Weaver
- Department of Pathology, University of Massachusetts Medical School
- Claudia Von Arx
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Manuela Mura
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Aline T. Marinho
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Haonan Lu
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Eloise V. N. Morecroft
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Evdoxia Karali
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Naomi E. Chayen
- Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London
- Edward W. Tate
- Department of Chemistry, Imperial College London
- Mollie Jurewicz
- Department of Pathology, University of Massachusetts Medical School
- Lawrence J. Stern
- Department of Pathology, University of Massachusetts Medical School
- Chiara Recchi
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- Hani Gabra
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-019-10966-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contribute to tumorigenesis.
