Frontiers in Psychiatry (Aug 2019)

Psychological Resilience Enhances the Orbitofrontal Network in the Elderly With Mild Cognitive Impairment

  • Sang Joon Son,
  • Bumhee Park,
  • Bumhee Park,
  • Jin Wook Choi,
  • Hyun Woong Roh,
  • Na-Rae Kim,
  • Jae Eun Sin,
  • Haena Kim,
  • Hyun Kook Lim,
  • Chang Hyung Hong

DOI
https://doi.org/10.3389/fpsyt.2019.00615
Journal volume & issue
Vol. 10

Abstract

Read online

Background: It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI).Methods: Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/amygdala (AMG)/hippocampus (HP)/parahippocampal gyrus (PHG) FC according to the different levels of resilience scale.Results: Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG (P < 0.05, Bonferroni corrected), between the right inferior OFG and left PHG (P < 0.05, Bonferroni corrected), and between the right middle OFG and left PHG (false discovery rate < 0.05).Conclusion: Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.

Keywords