Journal of Inflammation Research (Nov 2024)

Prevalence and Risk Factors of Thromboembolic Events in Dermatomyositis in China: A 10-Year Retrospective Analysis

  • Li L,
  • Ding T,
  • Shi Q,
  • Zhu H,
  • Ma Q,
  • Zhou M,
  • Yuan Y,
  • Wen Z,
  • Xu H,
  • Tan H,
  • Chen D

Journal volume & issue
Vol. Volume 17
pp. 9539 – 9547

Abstract

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Liubing Li,1,* Tangdan Ding,1,2,* Qiong Shi,1,* Hongji Zhu,1,2 Qinghua Ma,1,2 Mianjing Zhou,3 Ying Yuan,4 Zhihua Wen,5 Hongxu Xu,1,2 Hongxia Tan,1 Dubo Chen1 1Department of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of China; 2Department of Laboratory Medicine, Nansha Division of The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 511466, People’s Republic of China; 3Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; 4Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; 5Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dubo Chen; Hongxia Tan, Email [email protected]; [email protected]: Dermatomyositis (DM) is an autoimmune disease characterized by chronic muscle inflammation and weakness. Patients with DM are at an increased risk of thromboembolic events (TEs). This study aimed to investigate the prevalence of TEs in DM and to identify the independent predictors.Methods: A total of 543 patients hospitalized for DM within the past 10 years were analyzed retrospectively and compared with patients with DM with and without TEs for demographic, clinical, and laboratory characteristics. The independent predictors were analyzed using multivariate logistic regression analysis. The diagnostic performance was calculated by a receiver operating curve (ROC).Results: Twenty-two (4.1%) patients with DM had TEs, including 12 (54.5%) with venous thromboembolism and 10 (45.5%) with arterial thromboembolism. Multivariate logistic regression analysis demonstrated that glucocorticoid therapy (odds ratio (OR)=0.003, 95% confidence interval (CI) 0.00– 0.03, P 1.3 mg/L fibrinogen equivalent units) should be screened for TEs.Keywords: Dermatomyositis, thromboembolic events, prevalence, risk factors

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