Eurasian Chemico-Technological Journal (Mar 2022)

Novel 7-Aryliden-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl- 3-aryl-2H-pyrazolo[4,3-c]pyridine Hydrochloride: Synthesis and Structure

  • Zh.A. Koshetova,
  • V.K. Yu,
  • T.K. Iskakova,
  • N.A. Zhumanova,
  • K.M. Beketov,
  • A.E. Malmakova,
  • K.D. Praliyev,
  • T.M. Seilkhanov,
  • K.D. Berlin

DOI
https://doi.org/10.18321/ectj1147
Journal volume & issue
Vol. 24, no. 1

Abstract

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A Claisen-Schmidt type reaction of 1-(2-ethoxyethyl)piperidin-4-one with differ­ent aromatic aldehydes led to corresponding dienones with a yield of 65‒71%. 7-Arylidene-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-aryl-2H-pyrazolo[4,3-c]pyridines were synthesized by heterocyclization of 3,5-dia­rylidene-piperidin-4-ones with phenylhydrazine hydrochloride in methanol at 70 °C over 4‒6 h. The X-ray crystal structure determination of 7-(p-methoxy­benzyliden)-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-(p-methoxy­phenyl)-2H-pyrazolo[4,3-c]pyridine hydrochloride (the deposition number is CCDC 862410) was completed. The piperidine and pyrazoline rings are close to a chair and envelope conformations, respectively.

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