Genomic regression analysis of coordinated expression

Ling Cai; Qiwei Li; Yi Du; Jonghyun Yun; Yang Xie; Ralph J. DeBerardinis; Guanghua Xiao

doi:10.1038/s41467-017-02181-0

Nature Communications (Dec 2017)

Genomic regression analysis of coordinated expression

Ling Cai,
Qiwei Li,
Yi Du,
Jonghyun Yun,
Yang Xie,
Ralph J. DeBerardinis,
Guanghua Xiao

Affiliations

Ling Cai: Children’s Medical Center Research Institute at UT Southwestern Medical Center
Qiwei Li: Quantitative Biomedical Research Center at UT Southwestern Medical Center
Yi Du: Department of Bioinformatics at UT Southwestern Medical Center
Jonghyun Yun: Department of Mathematics at University of Texas at Arlington
Yang Xie: Quantitative Biomedical Research Center at UT Southwestern Medical Center
Ralph J. DeBerardinis: Children’s Medical Center Research Institute at UT Southwestern Medical Center
Guanghua Xiao: Quantitative Biomedical Research Center at UT Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-017-02181-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Somatic copy number alterations (SCNA) can confound gene co-expression analysis in cancers. Here the authors develop a method to remove the effects of SCNA in co-expression analysis, improving the analysis of network rewiring in cancer, and provide a database with adjusted data from TCGA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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