Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094

Qiang Wang; Yixuan Zhang; Mian Wang; Yi Tan; Xinxin Hu; Hongwei He; Chunling Xiao; Xuefu You; Yiguang Wang; Maoluo Gan

doi:10.1038/s41598-017-03769-8

Scientific Reports (Jun 2017)

Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094

Qiang Wang,
Yixuan Zhang,
Mian Wang,
Yi Tan,
Xinxin Hu,
Hongwei He,
Chunling Xiao,
Xuefu You,
Yiguang Wang,
Maoluo Gan

Affiliations

Qiang Wang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Yixuan Zhang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Mian Wang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Yi Tan: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Xinxin Hu: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Hongwei He: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Chunling Xiao: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Xuefu You: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Yiguang Wang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Maoluo Gan: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College

DOI: https://doi.org/10.1038/s41598-017-03769-8
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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Abstract Neo-actinomycins A and B (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5H-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete Streptomyces sp. IMB094. Their structures were elucidated by spectroscopic analyses. The presence of this ring system was proposed to originate from a condensation between actinomycin D (3) with α-ketoglutarate and pyruvate, respectively. Compound 1 showed potent cytotoxic activities against human cancer HCT116 and A549 cell lines in the nanomolar range (IC50: 38.7 and 65.8 nM, respectively) and moderate antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) strains.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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