SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development

Lucia Falbo; Erica Raspelli; Francesco Romeo; Simona Fiorani; Federica Pezzimenti; Francesca Casagrande; Ilaria Costa; Dario Parazzoli; Vincenzo Costanzo

doi:10.1038/s41467-020-15180-5

Nature Communications (Mar 2020)

SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development

Lucia Falbo,
Erica Raspelli,
Francesco Romeo,
Simona Fiorani,
Federica Pezzimenti,
Francesca Casagrande,
Ilaria Costa,
Dario Parazzoli,
Vincenzo Costanzo

Affiliations

Lucia Falbo: IFOM, The FIRC Institute of Molecular Oncology
Erica Raspelli: IFOM, The FIRC Institute of Molecular Oncology
Francesco Romeo: IFOM, The FIRC Institute of Molecular Oncology
Simona Fiorani: Clare Hall Laboratories, London Research Institute, Cancer Research UK
Federica Pezzimenti: IFOM, The FIRC Institute of Molecular Oncology
Francesca Casagrande: IFOM, The FIRC Institute of Molecular Oncology
Ilaria Costa: IFOM, The FIRC Institute of Molecular Oncology
Dario Parazzoli: IFOM, The FIRC Institute of Molecular Oncology
Vincenzo Costanzo: IFOM, The FIRC Institute of Molecular Oncology

DOI: https://doi.org/10.1038/s41467-020-15180-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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During embryonic development, it is vital to maintain rapid genome duplication. Here, the authors shed light on the mechanism by revealing that SSRP1 stimulates replication origin assembly on somatic nuclei in Xenopus laevis egg extract by promoting histone H1 eviction from somatic chromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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