Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review

Hridya Rao; Margaret C. Weiss; Jee Young Moon; Krista M. Perreira; Martha L. Daviglus; Robert Kaplan; Kari E. North; Maria Argos; Lindsay Fernández-Rhodes; Tamar Sofer

HGG Advances (Jan 2025)

Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review

Hridya Rao,
Margaret C. Weiss,
Jee Young Moon,
Krista M. Perreira,
Martha L. Daviglus,
Robert Kaplan,
Kari E. North,
Maria Argos,
Lindsay Fernández-Rhodes,
Tamar Sofer

Affiliations

Hridya Rao: Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA
Margaret C. Weiss: Department of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL, USA
Jee Young Moon: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
Krista M. Perreira: Department of Social Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Martha L. Daviglus: Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA
Robert Kaplan: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Kari E. North: Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Maria Argos: Department of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL, USA; Department of Environmental Health, School of Public Health, Boston University, Boston, MA, USA
Lindsay Fernández-Rhodes: Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA
Tamar Sofer: Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA; Corresponding author

Journal volume & issue: Vol. 6, no. 1
p. 100376

Abstract

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The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study’s inception in 2008, as a result of the study’s robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.

Published in HGG Advances

ISSN: 2666-2477 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Biology (General): Genetics
Website: https://www.cell.com/hgg-advances/home

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