Evolution of DNA methylation in the human brain

Hyeonsoo Jeong; Isabel Mendizabal; Stefano Berto; Paramita Chatterjee; Thomas Layman; Noriyoshi Usui; Kazuya Toriumi; Connor Douglas; Devika Singh; Iksoo Huh; Todd M. Preuss; Genevieve Konopka; Soojin V. Yi

doi:10.1038/s41467-021-21917-7

Nature Communications (Apr 2021)

Evolution of DNA methylation in the human brain

Hyeonsoo Jeong,
Isabel Mendizabal,
Stefano Berto,
Paramita Chatterjee,
Thomas Layman,
Noriyoshi Usui,
Kazuya Toriumi,
Connor Douglas,
Devika Singh,
Iksoo Huh,
Todd M. Preuss,
Genevieve Konopka,
Soojin V. Yi

Affiliations

Hyeonsoo Jeong: School of Biological Sciences, Georgia Institute of Technology
Isabel Mendizabal: School of Biological Sciences, Georgia Institute of Technology
Stefano Berto: Department of Neuroscience, UT Southwestern Medical Center
Paramita Chatterjee: School of Biological Sciences, Georgia Institute of Technology
Thomas Layman: School of Biological Sciences, Georgia Institute of Technology
Noriyoshi Usui: Department of Neuroscience, UT Southwestern Medical Center
Kazuya Toriumi: Department of Neuroscience, UT Southwestern Medical Center
Connor Douglas: Department of Neuroscience, UT Southwestern Medical Center
Devika Singh: School of Biological Sciences, Georgia Institute of Technology
Iksoo Huh: School of Biological Sciences, Georgia Institute of Technology
Todd M. Preuss: Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University
Genevieve Konopka: Department of Neuroscience, UT Southwestern Medical Center
Soojin V. Yi: School of Biological Sciences, Georgia Institute of Technology

DOI: https://doi.org/10.1038/s41467-021-21917-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

DNA methylation plays an important role in brain development and function. Here, the authors compare whole-genome methylation in neurons and oligodendrocytes in humans, chimpanzees and macaques to reconstruct evolution of DNA methylation at cell-type level, including in regions associated with schizophrenia heritability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal