On rheological properties erythrocyre at sick of the arterial hypertension with dyslipidemia

Abstract

Purpose: comparative investigation of the influence of several inhibitors hydroxymethylglutaril coenzyme A-reductase - Fluvastatin, Lovastatin and Simvastatin on rheological properties of erythrocytes in patients with arterial hypertension and dyslipidemia. The total number of examined and treated patients was 95. Arterial hypertension 1-2 degrees, risk 3 and dyslipidemia II type (recommendation VNOK, 2007) was revealed in all patients The average age of patients was 52,4 ± 2,6 years. The control group consisted of 26 healthy people of similar age. Patients have been divided into 3 comparable, homogeneous groups and were administered either Fluvastatin or Lovastatin or Simvastatin for 12 months in each group. Prescription of Fluvastatin and Lovastatin to patients with arterial hypertension and dyslipidemia for 1 year may reduce the activity of lipid peroxidation in erythrocyte membranes, its deformation changes and aggregation activity whereas one-year therapy by Simvastatin allows the erythrocyte's activity to reach the values of the control group.

Keywords

• эритроциты
• реология крови
• артериальная гипертония
• дислипидемия
• симвастатин