Nature Communications (Jun 2021)
Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids
- Yifei Liu,
- Bo Wang,
- Shaohua Shu,
- Zheng Li,
- Chi Song,
- Di Liu,
- Yan Niu,
- Jinxin Liu,
- Jingjing Zhang,
- Heping Liu,
- Zhigang Hu,
- Bisheng Huang,
- Xiuyu Liu,
- Wei Liu,
- Liping Jiang,
- Mohammad Murtaza Alami,
- Yuxin Zhou,
- Yutao Ma,
- Xiangxiang He,
- Yicheng Yang,
- Tianyuan Zhang,
- Hui Hu,
- Michael S. Barker,
- Shilin Chen,
- Xuekui Wang,
- Jing Nie
Affiliations
- Yifei Liu
- College of Pharmacy, Hubei University of Chinese Medicine
- Bo Wang
- Hubei Institute for Drug Control
- Shaohua Shu
- College of Plant Science and Technology, Huazhong Agricultural University
- Zheng Li
- Department of Ecology and Evolutionary Biology, University of Arizona
- Chi Song
- Wuhan Benagen Tech Solutions Company Limited
- Di Liu
- College of Pharmacy, Hubei University of Chinese Medicine
- Yan Niu
- Wuhan Benagen Tech Solutions Company Limited
- Jinxin Liu
- College of Plant Science and Technology, Huazhong Agricultural University
- Jingjing Zhang
- College of Pharmacy, Hubei University of Chinese Medicine
- Heping Liu
- College of Plant Science and Technology, Huazhong Agricultural University
- Zhigang Hu
- College of Pharmacy, Hubei University of Chinese Medicine
- Bisheng Huang
- College of Pharmacy, Hubei University of Chinese Medicine
- Xiuyu Liu
- National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Wei Liu
- College of Pharmacy, Hubei University of Chinese Medicine
- Liping Jiang
- College of Pharmacy, Hubei University of Chinese Medicine
- Mohammad Murtaza Alami
- College of Plant Science and Technology, Huazhong Agricultural University
- Yuxin Zhou
- Hubei Institute for Drug Control
- Yutao Ma
- College of Plant Science and Technology, Huazhong Agricultural University
- Xiangxiang He
- Wuhan Benagen Tech Solutions Company Limited
- Yicheng Yang
- Wuhan Benagen Tech Solutions Company Limited
- Tianyuan Zhang
- Wuhan Benagen Tech Solutions Company Limited
- Hui Hu
- Jing Brand Chizhengtang Pharmaceutical Company Limited
- Michael S. Barker
- Department of Ecology and Evolutionary Biology, University of Arizona
- Shilin Chen
- Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Xuekui Wang
- College of Plant Science and Technology, Huazhong Agricultural University
- Jing Nie
- Hubei Institute for Drug Control
- DOI
- https://doi.org/10.1038/s41467-021-23611-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Coptis chinensis represents an early-diverging eudicot lineage with diverse medicinal applications. Here, the authors report its chromosome-scale genome assembly, infer a single ancient whole-genome duplication, and characterize the function of CYP719 in diversification of protoberberine-type alkaloids.
