Genomic analysis of a Streptococcus pyogenes strain causing endocarditis in a child

Abstract

We sequenced the genome of Streptococcus pyogenes strain G773 that caused an infective endocarditis in a 4-year-old boy suffering from acute endocarditis. The 1.9-Mb genome exhibited a specific combination of virulence factors including a complete integrative and conjugative element, sp2905, previously described as incomplete in S. pyogenes, and five bacteriocin-coding genes. However, strain G773 lacked a CRISPR-Cas system.

Keywords

• Endocarditis
• genome comparison
• real-time genome sequencing
• Streptococcus pyogenes
• virulence