Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy

David Martino; Melanie Neeland; Thanh Dang; Joanna Cobb; Justine Ellis; Alice Barnett; Mimi Tang; Peter Vuillermin; Katrina Allen; Richard Saffery

doi:10.1038/s41467-018-05608-4

Nature Communications (Aug 2018)

Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy

David Martino,
Melanie Neeland,
Thanh Dang,
Joanna Cobb,
Justine Ellis,
Alice Barnett,
Mimi Tang,
Peter Vuillermin,
Katrina Allen,
Richard Saffery

Affiliations

David Martino: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne
Melanie Neeland: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne
Thanh Dang: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne
Joanna Cobb: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne
Justine Ellis: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne
Alice Barnett: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne
Mimi Tang: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne
Peter Vuillermin: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne
Katrina Allen: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne
Richard Saffery: Department of Paediatrics, Murdoch Children’s Research Institute, The University of Melbourne

DOI: https://doi.org/10.1038/s41467-018-05608-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Immunoglobulin E (IgE)-mediated food allergy is a major issue that affects 2–10% of infants. Here the authors study the epigenetic regulation of the naive CD4+ T cell activation response among children with IgE-mediated food allergy finding epigenetic dysregulation in the early stages of signal transduction through the T cell receptor complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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