Nature Communications (Nov 2021)

Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes

  • Sonali Jindal,
  • Nathan D. Pennock,
  • Duanchen Sun,
  • Wesley Horton,
  • Michelle K. Ozaki,
  • Jayasri Narasimhan,
  • Alexandra Q. Bartlett,
  • Sheila Weinmann,
  • Paul E. Goss,
  • Virginia F. Borges,
  • Zheng Xia,
  • Pepper Schedin

DOI
https://doi.org/10.1038/s41467-021-26505-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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The molecular differences between postpartum (PPBC) and nulliparous (NPBC) young women breast cancer (YWBC) patients remain unknown. Here the authors perform RNA sequencing and multiplex immunohistochemistry on an FFPE breast cancer cohort and suggest that PPBC is a unique entity within YWBC with poor prognosis.