The AGTR2 (RS11091046) Gene Polymorphism is Associated with Cycling Performance in Korean Cyclists

Abstract

Purpose This study aimed to investigate the association between AGTR2 (rs11091046 A>C) gene polymorphism and athletic performance. Methods The Korean national team cyclists enrolled in the study performed 30-second Wingate test (peak power, mean power, and power drop), one-repetition maximum (squat and bench press), and isokinetic dynamometer (60° extensor and flexor in both legs) to examine the power/sprint performance between the C and A alleles. Results The physical characteristics showed no significant difference between the C and A alleles. Comparison of physical fitness tests in cyclists revealed no significant difference between the two alleles in one-repetition maximum and isokinetic dynamometer. However, the C allele had a significantly higher peak power (10.46±0.82 vs. 9.92±0.57, p=.016) and mean power (8.30±0.48 vs. 7.95±0.47, p=.022) than A allele in the Wingate test. Conclusions Our results demonstrate that the AGTR2 gene C allele is associated with the power/sprint performance of the Korean national team cyclists.

Keywords

• agtr2
• genotype
• polymorphism
• athletic performance
• alleles