Crosslinked γ-cyclodextrin metal organic framework for stable ibuprofen loading

Abstract

Ibuprofen (IBU) is a commonly used non-steroidal anti-inflammatory drug (NSAIDs), but its solubility is poor in both aqueous and physiological environments . To improve its oral bioavailability and absorption, IBU is loaded into a material, with cyclodextrin metal–organic frameworks (CD-MOFs) being a promising drug carrier. To overcome the instability of CD-MOFs in humid conditions, a cross-linking agent Isophorone diisocyanate (IPDI) was introduced, and a novel cross-linked material CL-CD-MOFs was prepared. On this basis, two IBU-loaded materials, CL-CD-MOFs-IBU, were prepared through different reaction sequences. Research shows that CL-CD-MOFs exhibit stability in water and humid environments, whereas CD-MOFs readily dissolve. Furthermore, this material demonstrates higher IBU loading and encapsulation rates, as well as sustained drug release. Cell toxicity studies indicate that CL-CD-MOFs-IBU exhibit good biocompatibility.

Keywords

• cyclodextrin
• metal-organic framework
• ibuprofen
• crosslinking