In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT

Shaozhuang Yang; Liwei Liu; Yixin Chang; Ningning Zhang; Kun Liu; Liang Hong; Bingling Chen; Yue Zhao; Rui Hu; Junle Qu

doi:10.1142/S1793545819500019

Journal of Innovative Optical Health Sciences (Jan 2019)

In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT

Shaozhuang Yang,
Liwei Liu,
Yixin Chang,
Ningning Zhang,
Kun Liu,
Liang Hong,
Bingling Chen,
Yue Zhao,
Rui Hu,
Junle Qu

Affiliations

Shaozhuang Yang: Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China
Liwei Liu: Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China
Yixin Chang: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, P. R. China
Ningning Zhang: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, P. R. China
Kun Liu: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, P. R. China
Liang Hong: Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China
Bingling Chen: Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China
Yue Zhao: Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China
Rui Hu: Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China
Junle Qu: Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China

DOI: https://doi.org/10.1142/S1793545819500019
Journal volume & issue: Vol. 12, no. 1
pp. 1950001-1 – 1950001-10

Abstract

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In this paper, we proposed a contrast-enhanced homemade spectral domain optical coherence tomography (SD-OCT) method for monitoring of brain microcirculation. We used the polyethylene glycol (PEG)-ylated gold nanorods (GNRs) as a contrast-enhanced agent, obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood vessels. Owing to high scattering of the PEG-GNRs, more tiny blood vessels can be imaged and the OCT signal can be enhanced by 5.87 dB after injection of PEG-GNRs for 20min, the enhancement then declined gradually for 60min. Our results demonstrate an effective technique for the enhanced imaging of blood vessels in vivo, especially for studies of the brain microcirculation, which could be serviced for disease mechanism research and therapeutic drug monitoring.

Published in Journal of Innovative Optical Health Sciences

ISSN: 1793-5458 (Print); 1793-7205 (Online)
Publisher: World Scientific Publishing
Country of publisher: Singapore
LCC subjects: Technology; Science: Physics: Optics. Light
Website: http://www.worldscientific.com/worldscinet/jiohs

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