Nature Communications (Feb 2021)
Fecal microbiota transplantation in HIV: A pilot placebo-controlled study
- Sergio Serrano-Villar,
- Alba Talavera-Rodríguez,
- María José Gosalbes,
- Nadia Madrid,
- José A. Pérez-Molina,
- Ryan J. Elliott,
- Beatriz Navia,
- Val F. Lanza,
- Alejandro Vallejo,
- Majdi Osman,
- Fernando Dronda,
- Shrish Budree,
- Javier Zamora,
- Carolina Gutiérrez,
- Mónica Manzano,
- María Jesús Vivancos,
- Raquel Ron,
- Javier Martínez-Sanz,
- Sabina Herrera,
- Uxua Ansa,
- Andrés Moya,
- Santiago Moreno
Affiliations
- Sergio Serrano-Villar
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Alba Talavera-Rodríguez
- Bioinformatics Unit, Hospital Universitario Ramon y Cajal, IRYCIS
- María José Gosalbes
- Area of Genomics and Health, FISABIO-Salud Pública
- Nadia Madrid
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- José A. Pérez-Molina
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Ryan J. Elliott
- OpenBiome
- Beatriz Navia
- Department of Nutrition, Facultad de Farmacia, Universidad Complutense
- Val F. Lanza
- Bioinformatics Unit, Hospital Universitario Ramon y Cajal, IRYCIS
- Alejandro Vallejo
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Majdi Osman
- OpenBiome
- Fernando Dronda
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Shrish Budree
- OpenBiome
- Javier Zamora
- Barts and the London School for Medicine and Dentistry. Queen Mary University of London
- Carolina Gutiérrez
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Mónica Manzano
- Department of Nutrition, Facultad de Farmacia, Universidad Complutense
- María Jesús Vivancos
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Raquel Ron
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Javier Martínez-Sanz
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Sabina Herrera
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Uxua Ansa
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- Andrés Moya
- Area of Genomics and Health, FISABIO-Salud Pública
- Santiago Moreno
- Department of Infectious Diseases, Hospital Universitario Ramon y Cajal, and IRYCIS
- DOI
- https://doi.org/10.1038/s41467-021-21472-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
It is unknown whether capsulized fecal microbiota transplantation (FMT) can modify the microbiota of people with HIV. Here, the authors report the results of a pilot double-blind study, where 30 HIV-infected subjects on ART were randomized to either weekly oral FMT capsules or placebo for 8 weeks, and show that transplanted microbiota successfully engrafts and is able to attenuate HIV-associated dysbiosis.
