P189: Drosophila modeling reclassifies VoUS in EED and PRC2 members: Relevance for clinical interpretation and rare variant burden testing in populations

• William Gibson,
• Sharri Cyrus,
• Sònia Medina Giró,
• Tianshun Lian,
• Douglas Allan

Affiliations

William Gibson

Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada

Sharri Cyrus

Department of Laboratory Medicine and Pathology, Division of Laboratory Genetics and Genomics, Mayo Clinic, Rochester, MN

Sònia Medina Giró

Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada

Tianshun Lian

Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada

Douglas Allan

Department of Cellular & Physiological Sciences, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada