Инфекция и иммунитет (Dec 2018)

BIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS

  • O. B. Ogarkov,
  • A. E. Suzdalnitsky,
  • P. A. Khromova,
  • T. A. Tsyrenova,
  • N. A. Sokolnikova,
  • S. N. Zhdanova,
  • M. E. Koshcheev

DOI
https://doi.org/10.15789/2220-7619-2018-4-435-440
Journal volume & issue
Vol. 8, no. 4
pp. 435 – 440

Abstract

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Abstract. The data proving low probability of observing Biofilm Formation (BF) by contemporary clinical strains of M. tuberculosis growing on liquid medium in vitro are discussed. A hypothesis about the role of MDR/XDR development hindering BF production was proposed. It was found that strains capable of producing BF grow on Lewenstein–Jensen medium generated R-form specific colonies shaped as a disk with a convex center, “UFO-colonies”. Sixty seven “UFO”- strains were investigated to BF production, resistance to antibiotics and their belonging to the main epidemics clusters of the Beijing genotype (CC1 and CC2-W148). It was shown that MDR/XDR strains were also capable of BF production that, however, was remarkably more frequent in strains of CC1 and CC2-W148 genotypes. Thus, it was hypothesized that BF production might potentially influence an outcome of chronic forms of TB-infection.

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