Nature Communications (Nov 2018)

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

  • Sho Matsui,
  • Tsutomu Sasaki,
  • Daisuke Kohno,
  • Keisuke Yaku,
  • Ayumu Inutsuka,
  • Hiromi Yokota-Hashimoto,
  • Osamu Kikuchi,
  • Takayoshi Suga,
  • Masaki Kobayashi,
  • Akihiro Yamanaka,
  • Akihiro Harada,
  • Takashi Nakagawa,
  • Tatsushi Onaka,
  • Tadahiro Kitamura

DOI
https://doi.org/10.1038/s41467-018-07033-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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SIRT1 is a NAD+-dependent deacetylase whose functions have been linked to organismal longevity, aging and metabolism. Here, Matsui and colleagues show that neuronal SIRT1 can affect nutrient-related dietary choice in mice, and this effect is mediated by FGF21 signalling and oxytocin.