Physiological antioxidant system and oxidative stress in stomach cancer patients with normal renal and hepatic function

Abstract

Role of free radicals has been proposed in the pathogenesis of many diseases. Gastric cancer is a common disease worldwide, and leading cause of cancer death in India. Severe oxidative stress produces reactive oxygen species (ROS) and induces uncontrolled lipid peroxidation. Albumin, uric acid (UA) and Bilirubin are important physiological antioxidants. We aimed to evaluate and assess the role of oxidative stress (OS) and physiological antioxidant system in stomach cancer patients. Lipid peroxidation measured as plasma Thio Barbituric Acid Reactive substances (TBARS), was found to be elevated significantly (p=0.001) in stomach cancer compared to controls along with a decrease in plasma physiological antioxidant system. The documented results were due to increased lipid peroxidation and involvement of physiological antioxidants in scavenging free radicals but not because of impaired hepatic and renal functions.

Keywords

• Oxidative stress
• Lipid peroxidation
• Antioxidants
• Stomach cancer