Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration

Laetitia Keller; Luc Pijnenburg; Ysia Idoux-Gillet; Fabien Bornert; Laila Benameur; Maryam Tabrizian; Pierrick Auvray; Philippe Rosset; Rosa María Gonzalo-Daganzo; Enrique Gómez Barrena; Luca Gentile; Nadia Benkirane-Jessel

doi:10.1038/s41467-019-10165-5

Nature Communications (May 2019)

Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration

Laetitia Keller,
Luc Pijnenburg,
Ysia Idoux-Gillet,
Fabien Bornert,
Laila Benameur,
Maryam Tabrizian,
Pierrick Auvray,
Philippe Rosset,
Rosa María Gonzalo-Daganzo,
Enrique Gómez Barrena,
Luca Gentile,
Nadia Benkirane-Jessel

Affiliations

Laetitia Keller: INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS
Luc Pijnenburg: INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS
Ysia Idoux-Gillet: INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS
Fabien Bornert: INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS
Laila Benameur: Department of Biomedical Engineering, McGill University
Maryam Tabrizian: Department of Biomedical Engineering, McGill University
Pierrick Auvray: C.Ris Pharma, Parc Technopolitain - Atalante Saint-Malo
Philippe Rosset: Faculté de Médecine de Tours, CHRU de Tours, Service de Chirurgie Orthopédique 2, Université François Rabeleis
Rosa María Gonzalo-Daganzo: Unidad de Producción Celular, S° de Hematología y Hemoterapia, Hospital Universitario Puerta de Hierro Majadahonda
Enrique Gómez Barrena: Orthopaedic Surgery and Traumatology Department, Hospital La Paz-IdiPAZ and Universidad Autónoma de Madrid
Luca Gentile: INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS
Nadia Benkirane-Jessel: INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS

DOI: https://doi.org/10.1038/s41467-019-10165-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Arthroplasty is the main clinical option for the treatment of osteoarticular lesions, but has limited efficacy. Here, the authors use a wound dressing with autologous mesenchymal stromal cells, functionalised for local BMP2 delivery, and show feasibility and safety in standardised preclinical tests in animal models, suggesting suitability for use in clinical trials.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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