DNA Replication-Transcription Conflicts Do Not Significantly Contribute to Spontaneous Mutations Due to Replication Errors in Escherichia coli

Patricia L. Foster; Brittany A. Niccum; Heewook Lee

doi:10.1128/mBio.02503-21

mBio (Oct 2021)

DNA Replication-Transcription Conflicts Do Not Significantly Contribute to Spontaneous Mutations Due to Replication Errors in Escherichia coli

Patricia L. Foster,
Brittany A. Niccum,
Heewook Lee

Affiliations

Patricia L. Foster: ORCiD; Department of Biology, Indiana University, Bloomington, Indiana, USA
Brittany A. Niccum: Department of Biology, Indiana University, Bloomington, Indiana, USA
Heewook Lee: Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana, USA

DOI: https://doi.org/10.1128/mBio.02503-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Because DNA replication and transcription occur on the same DNA template, encounters between the two machines occur frequently. When these encounters are head-to-head, genomic disruption can occur.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal