Asian Journal of Andrology (Jan 2023)

Effect of advanced paternal age on reproductive outcomes in IVF cycles of non-male-factor infertility: a retrospective cohort study

  • Xin-Mei Lu,
  • Yu-Bing Liu,
  • Dou-Dou Zhang,
  • Xiang Cao,
  • Tian-Cheng Zhang,
  • Miao Liu,
  • Hui-Juan Shi,
  • Xi Dong,
  • Su-Ying Liu

DOI
https://doi.org/10.4103/aja202234
Journal volume & issue
Vol. 25, no. 2
pp. 245 – 251

Abstract

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Advanced paternal age has been overlooked, and its effect on fertility remains controversial. Previous studies have focused mainly on intracytoplasmic sperm injection (ICSI) cycles in men with oligozoospermia. However, few studies have reported on men with semen parameters within reference ranges. Therefore, we conducted a retrospective cohort study analyzing the reproductive outcomes of couples with non-male-factor infertility undergoing in vitro fertilization (IVF) cycles. In total, 381 cycles included were subgrouped according to paternal age ( 0.05). The pregnancy rate was not significantly different in the 35–39-year-old group (42.0%; P > 0.05), but was significantly lower in the ≥40-year-old group (26.1%; P 0.05), but showed a declining trend. The miscarriage rate significantly increased in the 35–39-year-old group (44.8%) compared with that in the <35-year-old group (21.0%; P < 0.05). No abnormality in newborn birth weight was found. The results indicated that paternal age over 40 years is a key risk factor that influences the assisted reproductive technology success rate even with good semen parameters, although it has no impact on embryo development.

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