Role of copper in type 2 Diabetes Mellitus: A mini-review

Abstract

Diabetes Mellitus (DM) presents a significant global health challenge, with escalating prevalence rates and associated morbidity and mortality. Despite medical advancements, the mortality rates continue to rise, necessitating a deeper understanding of the pathophysiology and potential therapeutic targets. Copper, a vital trace element, plays an important role in various metabolic processes and homeostatic functions within the human body. Dysregulation of copper metabolism has been implicated in the pathogenesis and progression of DM, contributing to oxidative stress, insulin resistance, altered glycemic control, and metabolic abnormalities. The present review provides an illustrative overview of the role of copper in DM, elucidating its impact on oxidative stress, insulin resistance, glycemic control, and metabolic disturbances.

Keywords

• diabetes
• hyperglycemia
• metabolic disorders
• trace elements
• insulin resistance