Nature Communications (Jun 2017)
Lkb1 maintains Treg cell lineage identity
- Di Wu,
- Yuechen Luo,
- Wei Guo,
- Qing Niu,
- Ting Xue,
- Fei Yang,
- Xiaolei Sun,
- Song Chen,
- Yuanyuan Liu,
- Jingru Liu,
- Zhina Sun,
- Chunxiao Zhao,
- Huifang Huang,
- Fang Liao,
- Zhongchao Han,
- Dongming Zhou,
- Yongguang Yang,
- Guogang Xu,
- Tao Cheng,
- Xiaoming Feng
Affiliations
- Di Wu
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Yuechen Luo
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Wei Guo
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Qing Niu
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Ting Xue
- Department of Medical Microbiology, Tongji Medical College, Huazhong University of Science and Technology
- Fei Yang
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Xiaolei Sun
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Song Chen
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Yuanyuan Liu
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Jingru Liu
- Central Laboratory, The Union Hospital of Fujian Medical University, 29 Xinquan Road
- Zhina Sun
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Chunxiao Zhao
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Huifang Huang
- Central Laboratory, The Union Hospital of Fujian Medical University, 29 Xinquan Road
- Fang Liao
- Department of Medical Microbiology, Tongji Medical College, Huazhong University of Science and Technology
- Zhongchao Han
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Dongming Zhou
- Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Yongguang Yang
- First Hospital of Jilin University
- Guogang Xu
- Nanlou Respiratory Department, Chinese PLA General Hospital
- Tao Cheng
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- Xiaoming Feng
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
- DOI
- https://doi.org/10.1038/ncomms15876
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune disease.
