Beta-adrenergic and M-cholinergic receptor interactions in the pathogenesis of bronchial obstructive pulmonary diseases

Abstract

The crosstalk between the beta-2-adrenoceptor and M- cholinoreceptor systems in the airways plays one of the main roles in the pathogenesis of bronchoobstructive diseases. The interaction of M3-cholinergic receptors and beta2-receptors in the lungs can be characterized as functional antagonism. M3 activation can lead to desensitization of beta2 receptors. Beta2 receptors also limit the action of M3 receptors in various ways. In this case, M2 cholinergic receptors act as autoreceptors. On the one hand, they limit bronchoconstriction caused by a change in the conformation of the M3 cholinergic receptor, and, on the other hand, they are able to suppress the excessive bronchorelaxing effect that occurs when a beta2 receptor is activated. The knowledge of the crosstalk mechanisms can help in understanding the pathogenesis of bronchial obstructive diseases, in optimizing the existing treatment regimens for chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA) and will create a new potential in the development of new drug groups

Keywords

• asthma
• copd
• beta2-adrenergic receptors
• ach-receptors
• beta-agonists
• anticholinergics