Nature Communications (Jun 2017)
MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
- Sean T. Bailey,
- Aleisha M. Smith,
- Jordan Kardos,
- Sara E. Wobker,
- Harper L. Wilson,
- Bhavani Krishnan,
- Ryoichi Saito,
- Hyo Jin Lee,
- Jing Zhang,
- Samuel C. Eaton,
- Lindsay A. Williams,
- Ujjawal Manocha,
- Dorien J. Peters,
- Xinchao Pan,
- Thomas J. Carroll,
- Dean W. Felsher,
- Vonn Walter,
- Qing Zhang,
- Joel S. Parker,
- Jen Jen Yeh,
- Richard A. Moffitt,
- Janet Y. Leung,
- William Y. Kim
Affiliations
- Sean T. Bailey
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Aleisha M. Smith
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Jordan Kardos
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Sara E. Wobker
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Harper L. Wilson
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Bhavani Krishnan
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Ryoichi Saito
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Hyo Jin Lee
- Department of Internal Medicine, Chungnam National University School of Medicine
- Jing Zhang
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Samuel C. Eaton
- Department of Pharmacology, University of North Carolina at Chapel Hill
- Lindsay A. Williams
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Ujjawal Manocha
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Dorien J. Peters
- Department of Pathology, Leiden University Medical Center
- Xinchao Pan
- Departments of Internal Medicine and Molecular Biology, UT Southwestern Medical Center
- Thomas J. Carroll
- Departments of Internal Medicine and Molecular Biology, UT Southwestern Medical Center
- Dean W. Felsher
- Department of Medicine, Stanford University School of Medicine
- Vonn Walter
- Department of Biochemistry and Molecular Biology, Penn State Milton S. Hershey College of Medicine
- Qing Zhang
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Joel S. Parker
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Jen Jen Yeh
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Richard A. Moffitt
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Janet Y. Leung
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- William Y. Kim
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- DOI
- https://doi.org/10.1038/ncomms15770
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC throughMYC activation and clear cell RCC through MYC activation combined with Vhl and Cdkn2adeletion.
