Synthesis of <i>N</i>-Substituted Iminosugar <i>C</i>-Glycosides and Evaluation as Promising <i>α</i>-Glucosidase Inhibitors

Abstract

A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor. Enzymatic kinetic assays indicated that compound 6e may be classified as an uncompetitive inhibitor. The study of structure-activity relationships of those iminosugars provided a starting point for the discovery of new α-glucosidase inhibitors.

Keywords

• iminosugars
• <i>C</i>-glycosides
• <i>α</i>-glucosidase
• inhibitors