Nature Communications (Apr 2019)
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
- Jun Zheng,
- Rong Fan,
- Huiqiong Wu,
- Honghui Yao,
- Yujie Yan,
- Jiamiao Liu,
- Lu Ran,
- Zhifang Sun,
- Lunzhao Yi,
- Li Dang,
- Pingping Gan,
- Piao Zheng,
- Tilong Yang,
- Yi Zhang,
- Tao Tang,
- Yang Wang
Affiliations
- Jun Zheng
- Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University
- Rong Fan
- Institute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine, Xiangya Hospital, Central South University
- Huiqiong Wu
- Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University
- Honghui Yao
- Xiangya School of Medicine, Central South University
- Yujie Yan
- Xiangya School of Medicine, Central South University
- Jiamiao Liu
- Xiangya School of Medicine, Central South University
- Lu Ran
- Yunnan Food Safety Research Institute, Kunming University of Science and Technology
- Zhifang Sun
- Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University
- Lunzhao Yi
- Yunnan Food Safety Research Institute, Kunming University of Science and Technology
- Li Dang
- Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University
- Pingping Gan
- Department of Oncology, Xiangya Hospital, Central South University
- Piao Zheng
- College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine
- Tilong Yang
- Southern University of Science and Technology
- Yi Zhang
- Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University
- Tao Tang
- Institute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine, Xiangya Hospital, Central South University
- Yang Wang
- Institute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine, Xiangya Hospital, Central South University
- DOI
- https://doi.org/10.1038/s41467-019-09601-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
There is interest in the development of drug-based hydrogels for responsive sustained drug release. Here, the authors report on the self-assembly of natural small molecule, rhein, into hydrogels and the application of the hydrogels as stable controlled release agents for neuro-inflammatory therapy
