Nanomaterials (May 2021)
SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2
- Elena Zavyalova,
- Oganes Ambartsumyan,
- Gleb Zhdanov,
- Dmitry Gribanyov,
- Vladimir Gushchin,
- Artem Tkachuk,
- Elena Rudakova,
- Maria Nikiforova,
- Nadezhda Kuznetsova,
- Liubov Popova,
- Bakhtiyar Verdiev,
- Artem Alatyrev,
- Elena Burtseva,
- Anna Ignatieva,
- Anna Iliukhina,
- Inna Dolzhikova,
- Alexander Arutyunyan,
- Alexandra Gambaryan,
- Vladimir Kukushkin
Affiliations
- Elena Zavyalova
- Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia
- Oganes Ambartsumyan
- Department of Microbiology, Virology and Immunology, I.M. Sechenov First Moscow State Medical University, 125009 Moscow, Russia
- Gleb Zhdanov
- Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia
- Dmitry Gribanyov
- Institute of Solid State Physics of Russian Academy of Science, 142432 Chernogolovka, Russia
- Vladimir Gushchin
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Artem Tkachuk
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Elena Rudakova
- Institute of Physiologically Active Compounds of Russian Academy of Science, 142432 Chernogolovka, Russia
- Maria Nikiforova
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Nadezhda Kuznetsova
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Liubov Popova
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Bakhtiyar Verdiev
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Artem Alatyrev
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Elena Burtseva
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Anna Ignatieva
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Anna Iliukhina
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Inna Dolzhikova
- National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N. F. Gamaleya, 123098 Moscow, Russia
- Alexander Arutyunyan
- Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
- Alexandra Gambaryan
- Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products RAS, 108819 Moscow, Russia
- Vladimir Kukushkin
- Institute of Solid State Physics of Russian Academy of Science, 142432 Chernogolovka, Russia
- DOI
- https://doi.org/10.3390/nano11061394
- Journal volume & issue
-
Vol. 11,
no. 6
p. 1394
Abstract
During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (DNA aptamers) provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection are either inapplicable for quantitative determination or have sophisticated and expensive construction and implementation. In this paper, we provide a SERS-aptasensor based on colloidal solutions which combines rapidity and specificity in quantitative determination of SARS-CoV-2 virus, discriminating it from the other respiratory viruses.
Keywords
