The oral KIF11 inhibitor 4SC‐205 exhibits antitumor activity and potentiates standard and targeted therapies in primary and metastatic neuroblastoma models

• Marc Masanas,
• Nuria Masiá,
• Leticia Suárez‐Cabrera,
• Mireia Olivan,
• Aroa Soriano,
• Blanca Majem,
• Laura Devis‐Jauregui,
• Rebeca Burgos‐Panadero,
• Carlos Jiménez,
• Pau Rodriguez‐Sodupe,
• Ariadna Boloix,
• Ignasi Toledano,
• Gabriela Guillén,
• Alexandra Navarro,
• David Llobet‐Navas,
• Alberto Villanueva,
• Josep Sánchez de Toledo,
• Josep Roma,
• Rosa Noguera,
• Lucas Moreno,
• Rolf Krauss,
• Soledad Gallego,
• Anna Santamaria,
• Miguel F. Segura

Affiliations

Marc Masanas

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Nuria Masiá

Cell Cycle and Cancer Laboratory Biomedical Research Group in Urology Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Leticia Suárez‐Cabrera

Cell Cycle and Cancer Laboratory Biomedical Research Group in Urology Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Mireia Olivan

Cell Cycle and Cancer Laboratory Biomedical Research Group in Urology Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Aroa Soriano

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Blanca Majem

Cell Cycle and Cancer Laboratory Biomedical Research Group in Urology Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Laura Devis‐Jauregui

Molecular Mechanisms and Experimental Therapy in Oncology‐Oncobell Program Bellvitge Biomedical Research Institute (IDIBELL) L'Hospitalet de Llobregat Spain

Rebeca Burgos‐Panadero

Group of Translational Research in Pediatric Solid Tumors Department of Pathology Medical School University of Valencia‐INCLIVA Biomedical Health Research Institute Valencia Spain

Carlos Jiménez

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Pau Rodriguez‐Sodupe

Quantitative Genomic Medicine Laboratory qGenomics Barcelona Spain

Ariadna Boloix

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Ignasi Toledano

Cell Cycle and Cancer Laboratory Biomedical Research Group in Urology Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Gabriela Guillén

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Alexandra Navarro

Department of Pathology Vall d'Hebron University Hospital Universitat Autònoma de Barcelona Barcelona Spain

David Llobet‐Navas

Molecular Mechanisms and Experimental Therapy in Oncology‐Oncobell Program Bellvitge Biomedical Research Institute (IDIBELL) L'Hospitalet de Llobregat Spain

Alberto Villanueva

Group of Chemoresistance and Predictive Factors Subprogram Against Cancer Therapeutic Resistance (ProCURE) ICO Oncobell Program IDIBELL L'Hospitalet del Llobregat Barcelona Spain

Josep Sánchez de Toledo

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Josep Roma

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Rosa Noguera

Group of Translational Research in Pediatric Solid Tumors Department of Pathology Medical School University of Valencia‐INCLIVA Biomedical Health Research Institute Valencia Spain

Lucas Moreno

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Rolf Krauss

4SC Martinsried Germany

Soledad Gallego

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Anna Santamaria

Cell Cycle and Cancer Laboratory Biomedical Research Group in Urology Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain

Miguel F. Segura

Group of Translational Research in Child and Adolescent Cancer Vall d'Hebron Research Institute (VHIR) ‐ Universitat Autònoma de Barcelona (UAB) Barcelona Spain