Nature Communications (Jan 2021)

Neutralizing antibody titres in SARS-CoV-2 infections

  • Eric H. Y. Lau,
  • Owen T. Y. Tsang,
  • David S. C. Hui,
  • Mike Y. W. Kwan,
  • Wai-hung Chan,
  • Susan S. Chiu,
  • Ronald L. W. Ko,
  • Kin H. Chan,
  • Samuel M. S. Cheng,
  • Ranawaka A. P. M. Perera,
  • Benjamin J. Cowling,
  • Leo L. M. Poon,
  • Malik Peiris

DOI
https://doi.org/10.1038/s41467-020-20247-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 7

Abstract

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Here, the authors perform plaque reduction neutralization (PRNT) assays quantitating SARS-CoV-2 specific neutralizing antibodies from 195 patients in different disease states and find that patients with severe disease exhibit higher peaks of neutralizing antibody titres than patients with mild or asymptomatic infections and that serum neutralizing antibody persists for over 6 months in most people.