Assessment of transient changes in oxygen diffusion of single red blood cells using a microfluidic analytical platform

Kevin Ziyang Chng; Yan Cheng Ng; Bumseok Namgung; Justin Kok Soon Tan; Soyeon Park; Sim Leng Tien; Hwa Liang Leo; Sangho Kim

doi:10.1038/s42003-021-01793-z

Communications Biology (Mar 2021)

Assessment of transient changes in oxygen diffusion of single red blood cells using a microfluidic analytical platform

Kevin Ziyang Chng,
Yan Cheng Ng,
Bumseok Namgung,
Justin Kok Soon Tan,
Soyeon Park,
Sim Leng Tien,
Hwa Liang Leo,
Sangho Kim

Affiliations

Kevin Ziyang Chng: Department of Biomedical Engineering, National University of Singapore
Yan Cheng Ng: Department of Biomedical Engineering, National University of Singapore
Bumseok Namgung: Department of Biomedical Engineering, National University of Singapore
Justin Kok Soon Tan: Department of Biomedical Engineering, National University of Singapore
Soyeon Park: Department of Biomedical Engineering, National University of Singapore
Sim Leng Tien: Department of Hematology, Singapore General Hospital
Hwa Liang Leo: Department of Biomedical Engineering, National University of Singapore
Sangho Kim: Department of Biomedical Engineering, National University of Singapore

DOI: https://doi.org/10.1038/s42003-021-01793-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 10

Abstract

Read online

Kevin Ziyang Chng et al. develop a microfluidic platform using a fluorescence quenching approach to assess transient changes in oxygen release rate of single red blood cells. They observe that biologically older red blood cells have a faster O2 release rate than younger cells and that storage of blood enhances this release rate.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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