Formation and Investigation of Electrospun Eudragit E100/Oregano Mats

Juste Baranauskaite; Erika Adomavičiūtė; Virginija Jankauskaitė; Mindaugas Marksa; Zita Barsteigienė; Jurga Bernatoniene

doi:10.3390/molecules24030628

Molecules (Feb 2019)

Formation and Investigation of Electrospun Eudragit E100/Oregano Mats

Juste Baranauskaite,
Erika Adomavičiūtė,
Virginija Jankauskaitė,
Mindaugas Marksa,
Zita Barsteigienė,
Jurga Bernatoniene

Affiliations

Juste Baranauskaite: Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Medical Academy, Sukileliu pr. 13, LT-50162 Kaunas, Lithuania
Erika Adomavičiūtė: Department of Production Engineering, Faculty of Mechanical Engineering and Design, Kaunas University of Technology, Studentu st. 56, LT-51424 Kaunas, Lithuania
Virginija Jankauskaitė: Department of Production Engineering, Faculty of Mechanical Engineering and Design, Kaunas University of Technology, Studentu st. 56, LT-51424 Kaunas, Lithuania
Mindaugas Marksa: Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, Medical Academy, A. Mickeviciaus g. 9, LT-44307 Kaunas, Lithuania
Zita Barsteigienė: Department of Pharmacognosy, Lithuanian University of Health Sciences, Medical Academy, A. Mickeviciaus g. 9, LT-44307 Kaunas, Lithuania
Jurga Bernatoniene: Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Medical Academy, Sukileliu pr. 13, LT-50162 Kaunas, Lithuania

DOI: https://doi.org/10.3390/molecules24030628
Journal volume & issue: Vol. 24, no. 3
p. 628

Abstract

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An electrospun mat of Eudragit E100 (EE100) (a cationic copolymer based on dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate) was used as a delivery system for oregano ethanolic extract (OEE). Oregano is a biologically active material which is widely used because of the antibacterial and antifungal activity. The oregano herb consists of phenolic compounds, the main of which are rosmarinic acid and from essential oil—carvacrol. Such a material could be an ideal candidate for oral drug systems. The influence of the EE100 concentration in the OEE on the structure of electrospun mats, encapsulation efficiency, dissolution profile, release kinetics and the stability of biologically active compounds was investigated. The concentration of the solution is a critical parameter for the structure and properties of electrospun mats. The diameter of electrospun fibers increased with the increase of EE100 concentration in the OEE. Electrospun mats obtained from 24% to 32% EE100 solutions showed high encapsulation efficiency, quick release and high stability of rosmarinic acid and carvacrol. Dissolution tests showed that 99% of carvacrol and 80% of rosmarinic acid were released after 10 min from electrospun nano-microfiber mats and capsules obtained from such formulations. The stability tests showed that physicochemical properties, dissolution profiles, and rosmarinic acid and carvacrol contents of the formulations were not significantly affected by storage.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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