A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

Deepak Tripathi; Sambasivan Venkatasubramanian; Satyanarayana S. Cheekatla; Padmaja Paidipally; Elwyn Welch; Amy R. Tvinnereim; Ramakrishna Vankayalapati

doi:10.1038/ncomms13896

Nature Communications (Dec 2016)

A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

Deepak Tripathi,
Sambasivan Venkatasubramanian,
Satyanarayana S. Cheekatla,
Padmaja Paidipally,
Elwyn Welch,
Amy R. Tvinnereim,
Ramakrishna Vankayalapati

Affiliations

Deepak Tripathi: Department of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler
Sambasivan Venkatasubramanian: Department of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler
Satyanarayana S. Cheekatla: Department of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler
Padmaja Paidipally: Department of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler
Elwyn Welch: Department of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler
Amy R. Tvinnereim: Department of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler
Ramakrishna Vankayalapati: Department of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler

DOI: https://doi.org/10.1038/ncomms13896
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes. Here the authors show that IL-22 produced by NK1.1+cells in the liver of streptozotocin T1D model mice can drive tolerance to allografted islets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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