A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells

Rupesh S. Patel; Rodrigo Romero; Emma V. Watson; Anthony C. Liang; Megan Burger; Peter M. K. Westcott; Kim L. Mercer; Roderick T. Bronson; Eric C. Wooten; Arjun Bhutkar; Tyler Jacks; Stephen J. Elledge

doi:10.1038/s41467-021-27731-5

Nature Communications (Jan 2022)

A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells

Rupesh S. Patel,
Rodrigo Romero,
Emma V. Watson,
Anthony C. Liang,
Megan Burger,
Peter M. K. Westcott,
Kim L. Mercer,
Roderick T. Bronson,
Eric C. Wooten,
Arjun Bhutkar,
Tyler Jacks,
Stephen J. Elledge

Affiliations

Rupesh S. Patel: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital
Rodrigo Romero: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Emma V. Watson: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital
Anthony C. Liang: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital
Megan Burger: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Peter M. K. Westcott: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Kim L. Mercer: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Roderick T. Bronson: Harvard Medical School
Eric C. Wooten: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital
Arjun Bhutkar: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Tyler Jacks: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Stephen J. Elledge: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital

DOI: https://doi.org/10.1038/s41467-021-27731-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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GATA-binding protein 4 (GATA4) is reported to control cell proliferation in cancers. Here the authors show that GATA4’s pro-inflammatory secretome promotes the recruitment of immune cells such as CD8 + T cells to suppress tumour initiation and growth in a non-cell autonomous manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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