MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation

Yu Zhao; Jiajian Zhou; Liangqiang He; Yuying Li; Jie Yuan; Kun Sun; Xiaona Chen; Xichen Bao; Miguel A. Esteban; Hao Sun; Huating Wang

doi:10.1038/s41467-019-13598-0

Nature Communications (Dec 2019)

MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation

Yu Zhao,
Jiajian Zhou,
Liangqiang He,
Yuying Li,
Jie Yuan,
Kun Sun,
Xiaona Chen,
Xichen Bao,
Miguel A. Esteban,
Hao Sun,
Huating Wang

Affiliations

Yu Zhao: Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Jiajian Zhou: Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Liangqiang He: Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Yuying Li: Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Jie Yuan: Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Kun Sun: Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Xiaona Chen: Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Xichen Bao: Laboratory of RNA Molecular Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Miguel A. Esteban: Laboratory of Chromatin and Human Disease, Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Hao Sun: Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Huating Wang: Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong

DOI: https://doi.org/10.1038/s41467-019-13598-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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Enhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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