Biochemical and hormonal parameters analysis of metoclopramide-induced hyperprolactinemic female wistar rats administered leaf extract of Kigelia africana

Abstract

Summary: Aim and Scope: To investigate the biochemical and hormonal parameters in metoclopramide-induced hyperprolactinemic female wistar rats administered leaf extract of Kigelia africana. Methods: A total of thirty female wistar rats were grouped into: (i) Normal control (n = 5) and (ii) Experimental (n =25) to induce hyperprolactinemia. The experimental group was divided into five groups of five animals each, given a total of six in all. Group 1 received the distilled water alone; Group2 was metoclopramide-induced hyperprolactinemic rats only; Group3 comprised of metoclopramide-induced hyperprolactinemic rats administered bromocriptine (2.5mgKg−1b.wt.) Groups 4–6 were metoclopramide-induced hyperprolactinemic rats administered 100, 200 and 400 mgKg−1 b.wt. K. africana methanol extract respectively. After treatments, biochemical and hormonal parameters were analyzed. Results: The study observed significant increase (P0.05) of cholesterol and protein levels were obtained in experimental rats treated with K.africana extract as against the normal control and hyperprolactinemia control. Conclusion: The extract, especially at the dosage of 400 mgKg−1b.wt could ameliorate hyperprolactinemia in rats. Fertility hormones can be improved by K.africana extract through its stimulatory effect.

Keywords

• Hyperprolactinemia
• Metoclopramide
• Bromocriptine
• Kigelia africana
• Hormonal and biochemical parameters