Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures

Junhong Kim; Na-Oh Yunn; Mangeun Park; Jihan Kim; Seongeun Park; Yoojoong Kim; Jeongeun Noh; Sung Ho Ryu; Yunje Cho

doi:10.1038/s41467-022-34292-8

Nature Communications (Oct 2022)

Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures

Junhong Kim,
Na-Oh Yunn,
Mangeun Park,
Jihan Kim,
Seongeun Park,
Yoojoong Kim,
Jeongeun Noh,
Sung Ho Ryu,
Yunje Cho

Affiliations

Junhong Kim: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
Na-Oh Yunn: Postech Biotech Center, Pohang University of Science and Technology (POSTECH)
Mangeun Park: Postech Biotech Center, Pohang University of Science and Technology (POSTECH)
Jihan Kim: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
Seongeun Park: Postech Biotech Center, Pohang University of Science and Technology (POSTECH)
Yoojoong Kim: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
Jeongeun Noh: Postech Biotech Center, Pohang University of Science and Technology (POSTECH)
Sung Ho Ryu: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
Yunje Cho: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)

DOI: https://doi.org/10.1038/s41467-022-34292-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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DNA aptamers can activate insulin receptor as selective agonists or positive allosteric modulators. Here, authors determine structures of the insulin receptor bound to aptamers and provide a basis for the selective activation or allosteric regulation of insulin receptor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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