mBio (Feb 2021)

Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption

  • Leila B. Giron,
  • Emmanouil Papasavvas,
  • Xiangfan Yin,
  • Aaron R. Goldman,
  • Hsin-Yao Tang,
  • Clovis S. Palmer,
  • Alan L. Landay,
  • Jonathan Z. Li,
  • John R. Koethe,
  • Karam Mounzer,
  • Jay R. Kostman,
  • Qin Liu,
  • Luis J. Montaner,
  • Mohamed Abdel-Mohsen

DOI
https://doi.org/10.1128/mBio.03444-20
Journal volume & issue
Vol. 12, no. 1

Abstract

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The likelihood of HIV rebound after stopping antiretroviral therapy (ART) is a combination of the size of HIV reservoirs that persist despite ART and the host immunological and inflammatory factors that control these reservoirs. Therefore, there is a need to comprehensively understand these host factors to develop a strategy to cure HIV infection and prevent viral rebound post-ART.