Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity

Zhao Zhang; Yu Xun; Shunxing Rong; Lijuan Yan; Jeffrey A. SoRelle; Xiaohong Li; Miao Tang; Katie Keller; Sara Ludwig; Eva Marie Y. Moresco; Bruce Beutler

doi:10.1038/s41467-022-31812-4

Nature Communications (Jul 2022)

Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity

Zhao Zhang,
Yu Xun,
Shunxing Rong,
Lijuan Yan,
Jeffrey A. SoRelle,
Xiaohong Li,
Miao Tang,
Katie Keller,
Sara Ludwig,
Eva Marie Y. Moresco,
Bruce Beutler

Affiliations

Zhao Zhang: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center
Yu Xun: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center
Shunxing Rong: Center for Human Nutrition, University of Texas Southwestern Medical Center
Lijuan Yan: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center
Jeffrey A. SoRelle: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center
Xiaohong Li: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center
Miao Tang: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center
Katie Keller: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center
Sara Ludwig: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center
Eva Marie Y. Moresco: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center
Bruce Beutler: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-022-31812-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Obesity is a major risk factor for fatty liver disease. Here, using a forward genetic screen, the authors identify the gene GM4951 as a GTPase involved in lipid oxidation and development of NAFLD in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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