TM9SF4 is an F-actin disassembly factor that promotes tumor progression and metastasis

Zhaoyue Meng; Zhichao Li; Mingxu Xie; Hongyan Yu; Liwen Jiang; Xiaoqiang Yao

doi:10.1038/s41467-022-33276-y

Nature Communications (Sep 2022)

TM9SF4 is an F-actin disassembly factor that promotes tumor progression and metastasis

Zhaoyue Meng,
Zhichao Li,
Mingxu Xie,
Hongyan Yu,
Liwen Jiang,
Xiaoqiang Yao

Affiliations

Zhaoyue Meng: School of Biomedical Sciences and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Zhichao Li: School of Biomedical Sciences and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Mingxu Xie: School of Biomedical Sciences and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Hongyan Yu: School of Biomedical Sciences and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Liwen Jiang: Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong
Xiaoqiang Yao: School of Biomedical Sciences and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong

DOI: https://doi.org/10.1038/s41467-022-33276-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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F-actin dynamics influence cancer cell motility. Here the authors show that TM9SF4 facilitates the cofilin-induced disassembly of F-actin to promote cancer cell migration and metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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